Organogenesis

CHALLENGE

Organogenesis

$1 MILLION (Prize amount to be confirmed. Announcement expected for next year)

Organ transplantion as of today, has several serious problems . It depends on organ donation, with a serious shortage of available organs for transplantion.

For medical practice it would be essential to have available organs from transplants with over 1M organs on demand annually at the moment.

Currently organs are donated from clinically dead people and require a complicated logistics and proper timing for being useful.

Even when the match is done between patient and donor, the time frame of survivalibity of the organ is very short. For those few patients getting na organ They have to take imune suppresion drugs for the rest of their lives. while the average organ transplant survival rate is nine years. Chronic rejection ends up being the outcome of almost all patients resulting in serious associated health complications.
Our system requires organs for trasnplantion that don`t carry all the limitations listed above, such as rejection, lack of donors, limited survival time.

Organogenesis is the phase of embryonic development that starts at the end of gastrulation and continues until birth. During organogenesis, the three germ layers formed from gastrulation (the ectoderm, endoderm, and mesoderm) form the internal organs of the organism.

The solution can include:

Developing technologies to control and manage organogenesis to produce the required organs is our goal.

This competition calls for strategies, technologies, concepts for the development of bio organs , possible through the patient stem cells to avoid rejection with new Technologies, including 3D printing and others that can guarantee the numbers required and the efficiency needed.

Proposal:

This is a two phase competition:

  • Phase 1: Written proposals, (max 30 pages including images) about the technologies and systems that would be utilized will select the five finalist that would proceed to phase 2.
  • Phase 2: To realize the required experiments under controlled conditions to prove the validity of their concept proposal.