Health CHALLENGE

CHALLENGE

ENDING-CANCER

$1 MILLION (Prize amount to be confirmed. Announcement expected for next year)

The end-cancer WORLDPRIZE is a prize purse totalling $10 Million. The competition incentives the talents around the world to create a integrated clinical solution which will improve patients average lifespan in 3 times the average survival rate without the treatment. The solution can include nutritional strategies, relaxation systems, chemotherapy, surgery, immunotherapy, metabolomics approaches, or any other strategy, as well as the use of a group of all the existing strategies to demonstrate the routes to double patients average life-expectancy (compared to the current survival rates from NCCN. It is expected that a company is created to implement the winning solution around the globe, in coordination with hospitals and governments worldwide. The solution has to prove being effective in 95% of all forms of cancer.

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CHALLENGE

Cancer Detection

$1 MILLION (Prize amount to be confirmed. Announcement expected for next year)

The number of patients with detection of the different types of cancer continue to rise for most types of cancer. A fundamental tool for survival is early cancer detection. This prize aims to incentivise and award the creation of a solution which allow cancer tests regularly, confortable, at everyone’s home. For example a device, which makes some kind of physical examination and sends the data to the web, and provides a propor cancer diagnosis. Early detection will mean a significantly larger number of saved lives.

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CHALLENGE

Human Health-Span and Longevity

$1 MILLION (Prize amount to be confirmed. Announcement expected for next year)

The end-cancer WORLDPRIZE is a prize purse totalling $10 Million. The competition incentives the talents around the world to create a integrated clinical solution which will improve patients average lifespan in 3 times the average survival rate without the treatment. The solution can include nutritional strategies, relaxation systems, chemotherapy, surgery, immunotherapy, metabolomics approaches, or any other strategy, as well as the use of a group of all the existing strategies to demonstrate the routes to double patients average life-expectancy (compared to the current survival rates from NCCN. It is expected that a company is created to implement the winning solution around the globe, in coordination with hospitals and governments worldwide. The solution has to prove being effective in 95% of all forms of cancer.

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CHALLENGE

HUMAN REJUVENATION

$1 MILLION (Prize amount to be confirmed. Announcement expected for next year)

Create and implement a method to rejuvenate (by several biological parameters) the biological age of a human in 10 years, of their evaluated age. The method can include the use of stem cell treatments, drugs for simulation of exercise, or any other strategy implemented by the teams. The treatments cannot take more than 3 months to apply to the patient. The winning teams are required to submit an entry that addressed several parameters, and needs to prove that their mixed approach rejuvenated the patient in at least 10 years (by all biological metric measurements: like heart pumping capacity, skin elasticity, etc…).

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CHALLENGE

CRYOPRSERVATION OF ORGANS

$1 MILLION (Prize amount to be confirmed. Announcement expected for next year)

During the last decades, researchers around the world have proven the capability of successfully cryopreserve semen, blood, embryos, stem cells, and other small cell samples. For medical practice it would be essential to have available organs for transplants. Currently organs are donated from clinically dead people, and require a complicated logistics, and proper timing for being useful. Even when viable, the organ recipient is required to take immune suppression drugs for the rest of his life, to avoid organ rejection. Successful preservation of entire human organs will decrease the cost of organ replacement and help the more than 100,000 patients currently on waiting lists for organ donation. The viable replacement of human organs would help postpone more than 30 percent of all deaths in the U.S.. It would also raises the human average longevity. The success of this prize will transform organ transplantation into one of the (economically) largest fields of current medicine. In the future, with a large supply of available cryopreserved organs, transplantation could serve other purposes, apart from survival surgery.

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CHALLENGE

CRYOPRESEVATION OF HUMANS

$1 MILLION (Prize amount to be confirmed. Announcement expected for next year)

Human cryopreservation is an essential technology which will have tremendous applications in the medical field, saving lives, for example in cases where patients are far from the hospital environment. Cryopreservation of humans will permit stopping time temporarily and safeguard the patients life. Another extremely likely important application of this technology is on space. Humanity is aiming to become a multi planetary species in the next decades, most notably with efforts from private companies like SpaceX. Interplanetary trips might require the use of reversible cryopreservation to eliminate the problems of very long trips between planets. The teams competing for this prize will have to prove that they can cryopreserve a dog down to -100ºC degrees, keep it for at least 24 hours under -100ºC degrees and afterwords revive the dog, proving that the dog’s memory was preserved as well as his physical and behavioural parameters.

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CHALLENGE

ALZEIMER’S AND PARKINSON’S DISEASE

$1 MILLION (Prize amount to be confirmed. Announcement expected for next year)

Neurodegenerative diseases, such as: Parkinson, Alzheimer, Huntington’s disease, dementia, and motor neuron diseases (such as Amyotrophic Lateral Sclerosis), are mainly caused by the gradual death of individual neurons and supporting glia leading to serious diminution in movement control, memory, cognition, mood and personality alterations, down to impairment in basic motor control such as an individual’s ability to carry out basic functions as walking and swallowing [AlzheimerA, 2013]. Also involved in Alzheimer’s is the loss of synapses, which is highly related to cognitive decline [Dekosky and Scheff, 1990; Terry et al., 1991; Scheff and Price, 2006]. Promising biotechnology-based approaches include transplantation of stem cells (reported to seriously help improve memory and learning in older mice models with Alzheimer’s, anticipating potential success for humans) [Tong, 2014]. Worldwide, there are 35.6 million people with Alzheimer, and the number is predicted to grow to 115.4 million people by 2050 [BDBN, 2012]. An estimated 5.2 million Americans have Alzheimer, making it the sixth leading cause of death in the United States. An estimated 203 billion dollars were spent treating Alzheimer’s patients, adding to the 216 billion dollars of unpaid care (calculated for the 17.5 billion hours spent by family and friends) [AlzheimerA, 2013]. This prize focuses on early detection of the disease and delaying of the disease progression. The winning team are expected to develop a system for effectively screen patients at risk for Alzheimer’s disease, and will also have to demonstrate the ability to improve cognitive function in late stage Alzheimer’s patients.

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CHALLENGE

HAPPINESS

$1 MILLION (Prize amount to be confirmed. Announcement expected for next year)

Happiness is not about the temporary pleasant feelings. Happiness might be related with the overall valuation that people make about their lives, bodies, minds and circumstances. Happy people tend to have healthier, more productive, and more fulfilling lives. The quantification of “global subjective happiness” has been the subject of research worldwide for several decades. The Happiness WORLDPRIZE intends to inspire everyone around the globe, including: doctors, psychologists, engineers, computer scientists, programmers, and many other to advance innovations in technologies for quantifying the global subjetive happiness on humans. WORLDPRIZES envisions a future where everyone can track the relation between life experiences and consequent impact on their personal happiness. Such information will help each one of us to choose and make informed decisions about our future and our allocation of time and resources to maximize our own happiness. The capacity to properly measure happiness would also empower decision makers in companies, governments, and other institutions to choose the proper interventions for increasing happiness of the stakeholders/citizens.

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CHALLENGE

REWALK

$1 MILLION (Prize amount to be confirmed. Announcement expected for next year)

The RECOVER WORLDPRIZE will award the prize to the team that implements a system that re-estores paraplegic individual to considered near-normal capability. The technology might be biological (for example using stem cells to restore the spinal cord damage) or might for example be technological involving a combination of a BMI system with an exoskeleton. By near-normal capability we consider the following: 1 – After treatment the patient is able to perform at least the following number of functions: standing, sitting and laying, including comfortably transition from one position to the other. 2 – Independently use the toilet. 3 – Naturally and comfortably climb stairs. 4 – Stand on a vertical position. 5 – walk 100 meters with not external help. 6 – run at 5 Km per hour for at least 100 meters. 7 – bike independently. Observation: all of these tasks have to be performed by the patient with hands-free function (for exemple via BMI using an EEG external sensor).

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CHALLENGE

BIONICS

$1 MILLION (Prize amount to be confirmed. Announcement expected for next year)

There are Million of people living without the, partial or complete, use of their legs / arms or hands due to limb loss. Today, for those patients missing one or both legs, have as only alternative wheelchairs or walker.

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CHALLENGE

ARTIFICIAL WOMB

$1 MILLION (Prize amount to be confirmed. Announcement expected for next year)

This prize aims to award the creation of an artificial womb where any type of extinct animal can be incubated. This is crucial for the creation of life in new planets, or for the revival os extinct especies, and to prevent un-necessary deaths on earth. Every day, approximately 830 women die from preventable causes related to pregnancy and childbirth, with 99% of all maternal deaths occur in developing countries. The World Health Organisation aims to, between 2016 and 2030, as part of the Sustainable Development Goals, to reduce the global maternal mortality ratio to less than 70 per 100 000 live births. This technology would help achieve this goal.

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CHALLENGE

ORGANOGENESIS

$1 MILLION (Prize amount to be confirmed. Announcement expected for next year)

Organ transplantation, as of today, has several serious problems. It depends on organ donation (with a serious shortage of available organs for transplantation, with approximaltey 1 million organs being needed worldwide annually). Even when a match is done between patient and donor, the time-frame of survivability of the organ is very short. For those few patients getting an organ, they have to take immune suppression drugs for the rest of their lives. For those patient which receive an organ, the median organ transplant survival rate is approximately nine years. Chronic rejection ends-up being the outcome of almost all patients, resulting in serious health complications associated.

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Health CHALLENGE

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ENDING-CANCER

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Cancer Detection

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Human Health-Span and Longevity

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HUMAN REJUVENATION

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CRYOPRSERVATION OF ORGANS

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CRYOPRESEVATION OF HUMANS

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ALZEIMER’S AND PARKINSON’S DISEASE

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HAPPINESS

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REWALK

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BIONICS

There are Million of people living without the, partial or complete, use of their legs / arms or hands due to limb loss. Today, for those patients missing one or both legs, have as only alternative wheelchairs or walker.

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ARTIFICIAL WOMB

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